The objective of this study was to investigate if a prolonged bleaching effect of carbamide\nperoxide-loaded hollow calcium phosphate spheres (HCPS) can be achieved. HCPS was synthesized\nvia a hydrothermal reaction method. Carbamide peroxide (CP) was-loaded into HCPS by mixing\nwith distilled water as solvent. We developed two bleaching gels containing CP-loaded HCPS: one\ngel with low HP concentration as at-home bleaching gel, and one with high HP concentration as\nin-office gel. Their bleaching effects on stained human permanent posterior teeth were investigated\nby measuring the color difference before and after bleaching. The effect of gels on rhodamine B\ndegradation was also studied. To investigate the potential effect of remineralization of using HCPS,\nbleached teeth were soaked in phosphate buffer solution (PBS) containing calcium and magnesium\nions. Both bleaching gels had a prolonged whitening effect, and showed a strong ability to degrade\nrhodamine B. After soaking in PBS for 3 days, remineralization was observed at the sites where HCPS\nattached to the teeth surface. CP-loaded HCPS could prolong the HP release behavior and improve\nthe bleaching effect. HCPS was effective in increasing the whitening effect of carbamide peroxide\nand improving remineralization after bleaching process.
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